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. 2017 Nov 10;10:32. doi: 10.1186/s13040-017-0152-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Analysis of specific subtypes in the TCGA breast cancer dataset. a Differential expression and correlation for the Luminal A and Luminal B comparison. The selected genes (in red) were further analyzed in panel (c). b Differential expression and correlation for the Basal-Like and Her2-Enriched comparison. The selected genes (in blue) were further analyzed in panel (d). c and (d) Genes whose difference in correlation is highest (in vertical) against the genes selected in (a) or (b) (in horizontal). Large network modules are framed by a dashed line. The difference of correlation is color-coded as shown in the left of (c) from −0.5 in greens to +0.5 in magentas. Genes in rows and columns were sorted according to hierarchical clustering using ward distance. The top trees were cut and joined by a dashed line for clarity