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. 2017 Nov 10;48:75. doi: 10.1186/s13567-017-0481-y

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Means and SEM of antibody isotype titers. IgM (A) and IgG (B) binding KLH, IgM (C) and IgG (D) binding MBP, and IgM (E) and IgG (F) binding PC-BSA of pigs (n = 56) in barren and enriched housing conditions measured on 7 different days. At 39 days of age, pigs were transported to the experimental rooms (T); at 44 days of age, BI and EI pigs were infected with PRRSV (P); at 52 days of age, BI and EI pigs were infected with A. pleuropneumoniae (A). H indicates the housing effect; I indicates the infection effect; D indicates the sampling day effect. ***P < 0.001, **P < 0.01, *P < 0.05, ^# P < 0.10.