Table 2.
The course of differential leukocyte counts and their ratios in the 20 subjects who develop malaria in CHMI-b
| Leukocytes × 109/L | Neutrophils × 109/L | Lymphocytes × 109/L | Monocytes × 109/L | NLCR | MLCR | NMCR | Parasite load parasites/mL | |
|---|---|---|---|---|---|---|---|---|
| Baseline | 5.1 (4.9–6.1) | 2.8 (2.5–3.1) | 1.6 (1.5–2.0) | 0.48 (0.35–0.60) | 1.8 (1.1–2.0) | 0.3 (0.2–0.3) | 5.8 (4.7–8.3) | N/A |
| DT − 2 | 5.8 (5.4–6.8) | 3.0 (2.3–3.7) | 2.1 (1.9–2.4) | 0.49 (0.43–0.61) | 1.4 (1.0–1.7) | 0.2 (0.2–0.3) | 5.6 (4.3–6.8) | 0 (0–0) |
| DT − 1 | 5.8 (5.3–6.6) | 2.9 (2.6–3.5) | 2.0 (1.5–2.3) | 0.55 (0.46–0.65) | 1.4 (1.1–2.1) | 0.3 (0.2–0.3) | 5.2 (4.5–6.7) | 0 (0–374) |
| DT | 5.6 (4.8–6.1) | 3.1 (2.8–3.6) | 1.6 (0.9–2.0) | 0.53 (0.40–0.58) | 2.2 (1.4–3.8) | 0.4 (0.4–0.5) | 6.4 (5.0–8.0) | 6265 (1306–12,152) |
| DT + 1 | 4.4 (3.9–4.7) | 3.0 (2.5–3.2) | 0.8 (0.6–1.1) | 0.44 (0.30–0.60) | 4.0 (2.2–5.3) | 0.5 (0.5–0.6) | 6.9 (5.4–9.5) | 1099 (159–19,494) |
| DT + 2 | 3.3 (2.9–4.0) | 1.9 (1.7–2.5) | 0.7 (0.6–1.2) | 0.32 (0.24–0.49) | 2.6 (1.7–3.7) | 0.5 (0.3–0.6) | 6.2 (4.1–8.0) | 100 (1–20,337) |
| DT + 3 | 3.4 (2.7–3.7) | 1.5 (1.3–1.9) | 1.0 (0.8–1.3) | 0.36 (0.28–0.60) | 1.6 (1.1–2.2) | 0.5 (0.3–0.6) | 3.6 (2.8–5.4) | 1 (0–305) |
| Day 35 | 6.2 (5.2–7.2) | 2.8 (2.3–3.3) | 2.2 (1.9–3.0) | 0.53 (0.44–0.71) | 1.2 (0.9–1.3) | 0.2 (0.2–0.2) | 5.6 (4.1–6.4) | 0 (0–0) |
| p value | < 0.0001 | < 0.0001 | < 0.0001 | 0.002 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 |
Data in this table are not normally distributed and shown as median (interquartile range). p values in this table were derived from Friedman tests