Table 1.
Responders | ||||
Patient ID | RECIST at Week 12 | Baseline LDH (U/L) | PFS (months)a | OS (months)a |
G1 | PR | 167 | Response ongoing | Alive |
G2 | PR | 215 | Response ongoing | Alive |
G3 | PR | 159 | Response ongoing | Alive |
G4 | PR | 217 | Response ongoing | Alive |
G5 | PR | 185 | Response ongoing | Alive |
G6 | PR | 206 | Response ongoing | Alive |
G7 | PR | 268 | Response ongoing | Alive |
G8 | PR | 167 | Response ongoing | Alive |
G9 | PR | 227 | Response ongoing | Alive |
G10 | PR | 187 | Response ongoing | Alive |
G11 | PR | 140 | Response ongoing | Alive |
G12 | CR | 150 | Response ongoing | Alive |
Non-responders | ||||
Patient ID | RECIST at Week 12 | Baseline LDH (U/L) | PFS (months)a | OS (months)a |
P1 | PD | 303 | 2.7 | 5.8 |
P2 | PD | 568 | 2.7 | 5.1 |
P3 | PD | 329 | 2.7 | 3.1 |
P4 | PD | 300 | 1.1 | Alive |
P5 | PD | 271 | 0.5 | Alive |
P6 | PD | 267 | 2.7 | Alive |
P7 | PD | 169 | 2.8 | Alive |
P8 | SD | 226 | 4 | Alive |
P9 | SD | 269 | 4.1 | Alive |
P10 | SD | 176 | 2.7 | 21.7 |
P11 | SD | 195 | Response ongoing | Alive |
P12 | SD | 402 | 5.5 | 8.3 |
Abbreviations: PR partial response, SD stable disease, PD progressive disease, CR complete response, LDH lactate dehydrogenase, PFS progression free survival, OS overall survival, U/L units per liter
aData cut off on 30th April, 2017. 11 out of 24 patients had progressed at time of analysis, all of whom were in the non-responders group. Median follow-up for these patients is 24.3 months. Normal range of LDH is 120–250 U/L