Figure 1.

(A) The number of sessions required to meet criterion (at least 60 reinforcers for three consecutive or five non-consecutive days) in the shaping task is presented as a function of biological sex, representing both HIV-1 Tg and control animals by collapsing across genotype (±95% CI). A first-order polynomial provided a well-described fit for male animals (R²: 0.95), with all animals meeting criterion within 8 days. In sharp contrast, a one-phase association was the best fit for female animals (R²: 0.94). All female animals acquired the task within 43 days. (B) A global one-phase association was the best fit for male HIV-1 Tg and male control animals (R²: 0.98), suggesting no difference in the number of days to meet criterion between genotypes. (C) In female control animals, a one-phase association provided a well-described fit (R²: 0.96). However, in female HIV-1 Tg animals, shaping acquisition was best fit using a first-order polynomial (R²: 0.91). Presence of the HIV-1 transgene had a significant effect on the temporal acquisition of shaping in female, but not male, animals.