Table 1. ncRNAs affecting SASP factor production.

MicroRNAs, lncRNAs, and circRNAs implicated in regulating SASP factors. The specific ‘Target SASP factors’ affected by the regulatory ncRNAs are listed; ‘[SASP mRNAs]’ denotes general regulation of the SASP phenotype by a given ncRNA. ‘Effector molecules’ are proteins and microRNAs through which some ncRNAs affect SASP gene expression programs.

	ncRNA	Target SASP factor	Effector molecules	References
microRNAs	miR-146a/b	IL6, IL8	IRAK1, TLR8	[52–54]
	miR-335	MMP2, IL6	PTEN	[55]
	miR-15b	[SASP mRNAs]	SIRT4	[56]
	miR-187	IL6, TNF mRNAs		[57]
	miR-9	IL6 mRNA		[58]
	miR-21	IL6, TNF, IL10	TLR8, PDCD4	[59, 60]
	miR-222	MMP1, SOD1 mRNAs		[61]
	miR-34a	[SASP mRNAs]	SIRT1	[62]
	miR-125b	TNF, MMP13 mRNAs		[63, 64]
	miR-152	MMP3 mRNA		[65]
	miR-147	TNF, IL6	(negative feedback?)	[66]
	miR-199a	[SASP mRNAs]	IKBKB	[67]
lncRNAs	lncRNA-LET	CCL2, CXCL1, IL6 mRNAs	NF90	[81, 82]
	LincRNA-Cox2	IL6 mRNA	HNRNPA/B, HNRNPA2/B1	[83]
	NEAT1	IL8 mRNA	SFPQ	[85]
	lnc-IL7R	SELE, VCAM1, IL6, IL8	(negative feedback?)	[86, 87]
	Lethe	[SASP mRNAs]	NF-κB	[88, 89]
	THRIL	TNF mRNA	HNRNPL	[90]
circRNA	Circ-Foxo3	[SASP mRNAs]	FAK, HIF1A, ID1, E2F1	[97]
	CircPVT1	[SASP mRNAs]	Let-7 sequestration	[98]