Figure 3. IL-22 mediated restoration of proliferation is dependent on STAT3 in intestine epithelial cells.
Ki-67 staining on distal ileum sections of wildtype (n = 7-13), ***p < 0.001 by One-Way ANOVA with Tukey post-hoc compared to all groups, and VillinCre STAT3-/- knockout (n = 3-5) **p < 0.01 by One-Way ANOVA with Tukey post-hoc compared to sham groups. Wildtype data are expressed as the mean of two independent experiments. Quantification was blinded and expressed as the number of Ki-67+ proliferating cells per crypt.