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. 2017 Nov 7;8:799. doi: 10.3389/fphar.2017.00799

Figure 5.

Figure 5

Effect of drug-binding kinetics on APD90, ERP, CaTamp, and diastolic [Ca2+]i for an open and inactivated state blocker. (A) APD90 (at 1 Hz), (B) ERP (at 3 Hz), (C,D) CaTamp (at 1 and 3 Hz), and (E,F) diastolic [Ca2+]i (at 1 and 3 Hz) are plotted for open and inactivated state blockers with varying binding kinetics, which were simulated via permutations of nine different drug-binding rates of (from 0.01 to 100 s−1) while keeping kon,O = kon,I and koff,O = koff,I. CaTamp is 103.6, 109.4, and 120.4 nM at 1 Hz, and 103.4, 120.4, and 135.9 nM at 3 Hz for drug-free, 50 and 100% IKur block, respectively. Diastolic [Ca2+]i is 157.6, 160.0, and 165.2 nM at 1 Hz, and 253.3, 266.9, and 286.9 nM at 3 Hz for drug-free, 50 and 100% IKur block, respectively.