Table 4.
Details of the overlap of underactivity and overactivity of mitochondrial enzymology function
| Enzyme affected | Cpx I Abn | Cpx I under active | Cpx I over active | Cpx IV Abn | Cpx IV under active | Cpx IV over active | Citrate Syn Abn | Citrate Syn under active | Citrate Syn over active |
|---|---|---|---|---|---|---|---|---|---|
| Complex I (n = 29) | 72% (21) | 28% (8) | 14% (4) | 3% (1) | 10% (3) | 28% (8) | 7% (2) | 21% (6) | |
| Underactive (n = 21) | 14% (3) | 5% (1) | 10% (2) | 29% (6) | 10% (2) | 19% (4) | |||
| Overactive (n = 8) | 13% (1) | 0% (0) | 13% (1) | 25% (2) | 0% (0) | 25% (2) | |||
| Complex IV (n = 8) | 50% (4) | 38% (3) | 13% (1) | 25% (2) | 75% (6) | 50% (4) | 25% (2) | 25% (2) | |
| Underactive (n = 2) | 50% (1) | 50% (1) | 0% (0) | 100%(2) | 0% (0) | 100% (2) | |||
| Overactive (n = 6) | 50% (3) | 33% (2) | 17% (1) | 33% (2) | 33% (2) | 0% (0) | |||
| Citrate Syn (n = 19) | 42% (8) | 32% (6) | 11% (2) | 21% (4) | 11% (2) | 11% (2) | 11% (2) | 89% (17) | |
| Underactive (n = 2) | 100% (2) | 100% (2) | 0% (0) | 100% (2) | 0% (0) | 100%(2) | |||
| Overactive (n = 17) | 35% (6) | 24% (4) | 12% (2) | 12% (2) | 12% (2) | 0% (0) |