Table 2.
Cox regression analyses of overall survival in patients with glioblastoma.
| Crude HR (95% CI) | P-value | Adjusted HR (95% CI) | P-value | |
|---|---|---|---|---|
| Diagnostic age | 1.036 (1.035, 1.037) | <0.001* | 1.030 (1.028, 1.032) | <0.001* |
| GENDER | ||||
| Female vs. Male | 1.059 (1.021, 1.080) | 0.001* | ||
| RACE | ||||
| Black vs. White | 0.901 (0.849, 0.956) | 0.001* | 0.919 (0.843, 1.003) | 0.057 |
| American Indian/Alaska Native vs. White | 0.883 (0.703, 1.110) | 0.286 | 1.130 (0.841, 1.518) | 0.417 |
| Asian or Pacific Islander vs. White | 0.797 (0.744, 0.855) | <0.001* | 0.769 (0.699, 0.847) | <0.001* |
| REGISTRY SITE | ||||
| South vs. Northeast | 1.175 (1.123, 1.230) | <0.001* | 1.245 (1.163, 1.332) | <0.001* |
| North Central vs. Northeast | 1.108 (1.047, 1.172) | <0.001* | 1.167 (1.075, 1.267) | <0.001* |
| West vs. Northeast | 1.102 (1.059, 1.146) | <0.001* | 1.102 (1.038, 1.170) | <0.001* |
| MARITAL STATUS | ||||
| Married vs. Single | 1.179 (1.133, 1.227) | <0.001* | 0.905 (0.853, 0.959) | 0.001* |
| INSURANCE RECODE | ||||
| Any Medicaid vs. Uninsured | 1.174 (1.058, 1.301) | 0.002* | 1.061 (0.940, 1.198) | 0.335 |
| Insured vs. Uninsured | 1.133 (1.033, 1.242) | 0.008* | 0.926 (0.831, 1.033) | 0.170 |
| LATERALITY | ||||
| One side involvement vs. Not a paired site | 0.736 (0.711, 0.763) | <0.001* | 0.858 (0.811, 0.907) | <0.001* |
| Bilateral involvement vs. Not a paired site | 1.202 (1.071, 1.350) | 0.002* | 0.886 (0.748, 1.050) | 0.164 |
| Paired site vs. Not a paired site | 0.846 (0.734, 0.974) | 0.020* | 1.027 (0.794, 1.327) | 0.840 |
| HISTOLOGICAL CLASSIFICATION | ||||
| Giant cell glioblastoma vs. Glioblastoma | 0.685 (0.589, 0.795) | <0.001* | ||
| Gliosarcomavs. Glioblastoma | 0.907 (0.827, 0.995) | 0.039* | ||
| EXTENT OF DISEASE | ||||
| Regional vs. Localized | 1.456 (1.405, 1.508) | <0.001* | 1.383 (1.313, 1.456) | <0.001* |
| Distant vs. Localized | 1.591 (1.419, 1.783) | <0.001* | 1.500 (1.275, 1.766) | <0.001* |
| TUMOR SIZE | ||||
| 25–49 vs. < 25 mm | 1.049 (0.995, 1.105) | 0.076 | 1.076 (1.007, 1.149) | 0.030* |
| 50–99 vs. < 25 mm | 1.178 (1.114, 1.239) | <0.001* | 1.206 (1.127, 1.291) | <0.001* |
| ≥100 vs. < 25 mm | 1.259 (0.953, 1.663) | 0.105 | 1.291 (0.875, 1.906) | 0.198 |
| EXTENSION OF TUMOR | ||||
| Yes vs. No | 0.903 (0.850, 0.959) | 0.001* | ||
| METASTASIS AT DIAGNOSIS | ||||
| Yes vs. No | 1.500 (1.328, 1.693) | <0.001* | ||
| TREATMENT | ||||
| Only surgery vs. no surgery and radiation | 0.542 (0.515, 0.570) | <0.001* | 0.630 (0.583, 0.681) | <0.001* |
| Radiation vs. no surgery and radiation | 0.381 (0.361, 0.402) | <0.001* | 0.403 (0.371, 0.437) | <0.001* |
| Surgery+Radiation vs. no surgery and radiation | 0.200 (0.192, 0.209) | <0.001* | 0.231 (0.215, 0.248) | <0.001* |
*
indicates significant factors, P < 0.05.