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. 2017 Nov 7;8:2173. doi: 10.3389/fmicb.2017.02173

FIGURE 1.

FIGURE 1

Putative eukaryotic-like protein kinases (ePKs) in Sulfolobus islandicus REY15A. (A) Domain organization of the protein kinases. The domains were predicted according to database of NCBI (https://www.ncbi.nlm.nih.gov/) and UniProt (http://www.uniprot.org/) and are shown in boxes with the amino acid numbers being indicated on the right. (B) Alignment of the core catalytic domains of the predicted ePKs. The sequences were analyzed by ClustalW. The conserved HRD motif within subdomain VIb is indicated in dashed boxes. The HRD motif in SiRe_0181 and SiRe_1531 are identified according to the studies on their homologs (Sso2387 and Sso0469, respectively) from S. solfataricus (Lower and Kennelly, 2003; Lower et al., 2004). The consensus sequences of the motifs are depicted above the lines: uppercase, universally conserved amino acid residues; lowercase, highly conserved amino acid residues.