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Akt and ERK regulate the AD0157-induced apoptosis in human myeloid leukemia cells. (A) Representative blots of p-ERK, total ERK, p-Akt and total Akt in HL60, U937 and KU812F upon treatment (14 h) with the indicated concentrations of AD0157 and stimulation with FBS 20% (30 min). (B) Percentage of p-ERK/ERK and p-Akt/Akt ratios in untreated and treated cells, expressed as means ± SD of three independent assays. #p < 0.005 and ∗∗p < 0.001 versus control.
