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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2017 Jul 8;23(11):1879–1886. doi: 10.1016/j.bbmt.2017.06.026

Table 3.

Variables associated with transplant outcome

N Death
N
2-year OS (95% CI) Relapse
N
2-year CIR (95% CI)
Remission status at BMT1
Non-CR1 4 3 25% (1–67%) 2 50% (0–100%)
CR1 21 2 88% (60–97%) 5 34% (8–60%)
Conditioning intensity1,2
Ablative 22 3 83% (56–94%) 4 26 (3–49%)
Reduced 3 2 NA (NA) 3 NA (NA)
TBI containing conditioning1
No 10 4 53% (17–79%) 5 56% (19–93%)
Yes 15 1 92% (54–99%) 2 19% (0–45%)
Induction type2
ALL-type 8 3 43% (6–78%) 5 NA (NA)
AML-type 17 2 87% (58–97%) 2 15% (0–36%)
MPAL Subtype2 *
B/Myeloid 8 1 83% (27–98%) 0 0% (0–0%)
T/Myeloid 7 0 100% (100–100%) 3 49% (3–94%)
Ph+ MPAL 5 2 60% (13–88%) 1 20% (0–60%)
MLL MPAL 4 2 50% (6–85%) 3 NA (NA)
Age (years)
≥18 21 3 83% (55–94%) 5 32% (7–58%)
<18 4 2 50% (6–85%) 2 50% (0–100%)
Diagnostic WBC2
≤13.5x10^9/L 10 0 100% (100–100%) 0 0% (0–0%)
>13.5x10^9/L 11 5 80% (39–95%) 4 49% (10–89%)
Cytogenetics
No complex karyotype 16 3 77% (44–92%) 4 29% (3–55%)
Complex karyotype 9 2 76% (33–94%) 3 51% (3–99%)
No monosomy 20 4 74% (44–90%) 4 26% (2–49%)
Monosomy 5 1 80% (20–97%) 3 60% (6–100%)
GVHD prophylaxis
Non-TCD 13 2 82% (44–95%) 5 48% (13–83%)
TCD 12 3 69% (30–89%) 2 22% (0–51%)
Donor
HLA Mismatched 10 2 73% (28–93%) 1 11% (0–33%)
HLA Matched 15 3 77% (44–92%) 6 50% (19–80%)
Cell source
Peripheral blood or bone marrow 19 5 69% (40–86%) 7 44% (18–69%)
Cord blood 6 0 100% (100–100%) 0 0% (0–0%)
MRD at time of transplant
No 13 4 65% (31–86%) 3 26% (0–54%)
Yes 9 0 100% (100–100%) 1 25% (0–74%)
1

A significant variable in OS;

2

A significant variable in relapse.

#

Ablative conditioning was busulfan based (n=4); clofarabine, melphalan and thiotepa (n=2); TBI based (n=9); or other.

*

One patient with NOS MPAL was not included in the survival analysis.

CIR: Cumulative incidence rate; NA: not available; MRD: minimal residual disease, TBI: total body irradiation.