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. 2017 Nov 8;8:1519. doi: 10.3389/fimmu.2017.01519

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Copyright © 2017 Qiu, Liu, Liang, Nie and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Emodin hinders dendritic cell (DC) maturation posttransplantation. Draining lymph node (LN) and spleen cells were isolated from B6 recipient mice that were transplanted with BALB/c skin and treated with CsA and/or emodin. 10 days after allogeneic skin transplantation, CD11c⁺CD86⁺ (A) and CD11c⁺CD80⁺ (B) DCs in recipients were enumerated by flow cytometry. Bar graphs represent the absolute numbers of the DCs. Data were pooled from three separate experiments and presented as means ± SD (n = 6–9 mice).