FIGURE 2.

Histology. Representative hematoxylin–eosin stained sections of colonic specimens harvested from vehicle-treated normal mice, non-operated (A) or splenectomized (D), and from TNBS-treated mice administered with vehicle, non-operated (B) or splenectomized (E), or with AR-R17779 1.5 mg/kg, non-operated (C) or splenectomized (F). TNBS colonic instillation caused mucosal necrosis, neutrophils infiltration and submucosal oedema (indicated by arrows) in vehicle-treated animals (B,E), attenuated by AR-R17779 treatment in non-operated mice (C) but not in splenectomized animals (F).