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. 2017 Nov 8;8:809. doi: 10.3389/fphar.2017.00809

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Copyright © 2017 Grandi, Zini, Flammini, Cantoni, Vivo, Ballabeni, Barocelli and Bertoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Splenectomy abolished the protective effects of AR-R17779 on TNBS-induced colitis. Disease Activity Index (A), macroscopic score (B), colonic length (C), colonic thickness (D), colonic MPO (E) and lung MPO (F) activity assessed in vehicle-treated normal mice (N; SPX/N) and in TNBS-treated mice administered with vehicle (CTR; SPX/C) or AR-R17779 1.5 mg/kg (A1.5; SPX/A), non-operated (black bars) or subjected to SPX (white bars) (n = 10–13 independent values per group). A1.5 values were the same already represented in Figure 3. ^∗P < 0.05 vs. N mice; ^#P < 0.05 vs. CTR mice; NS: not significant vs. N and CTR mice; two-way ANOVA followed by Bonferroni’s post-test.