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. 2017 Nov 8;8:809. doi: 10.3389/fphar.2017.00809

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Copyright © 2017 Grandi, Zini, Flammini, Cantoni, Vivo, Ballabeni, Barocelli and Bertoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Splenectomy abolished the effects of AR-R17779 on cytokines levels in TNBS-induced colitis. Colonic concentrations of IL-1β (A), IL-6 (B), IFNγ (C), and IL-10 (D) in vehicle-treated normal mice (N; SPX/N) and in TNBS-treated mice administered with vehicle (CTR; SPX/C) or AR-R17779 1.5 mg/kg (A1.5; SPX/A), non-operated (black bars) or subjected to SPX (white bars) (n = 7 independent values per group). ^∗P < 0.05 vs. N mice; ^#P < 0.05 vs. CTR mice; NS: not significant vs. N and CTR mice; two-way ANOVA followed by Bonferroni’s post-test.