| TRIGR (trial to Reduce IDDM in the genetically at risk) (17) |
To determine if avoidance of cow’s milk protein will protect high risk newborns from initiation of B cell autoimmunity and prevent T1D |
Expected 2017 |
| FINDIA (18) |
To test if weaning to a bovine insulin-free cow’s milk formula reduces T1D associated antibodies in genetically at risk children |
Compared to regular cow’s milk formula weaning to insulin-free cow’s milk formula reduced autoantibodies by age 3 years |
| BABYDIET (19) |
Delay of introduction of gluten to prevent islet autoimmunity in infants with 1st degree relative with T1D and high risk HLA genotype |
No difference in islet autoantibodies or development of diabetes |
| ENDIT (20) |
Nicotinamide vs. placebo in ICA-positive relative of patients with T1D to prevent T1D |
No difference in the development of T1D in those treated with nicotinamide compared to placebo |
| DPT-1 (21) |
Oral insulin and parenteral insulin to alter the immune response and reduce islet destruction in 1st and 2nd degree relatives of patients with T1D |
Oral/parenteral insulin did not delay or prevent T1D |
| DiAPREV-IT trial (22) |
Prevention trial with Diamyd a GAD65 “vaccine” in children with positive islet cell antibodies |
Does not prevent development of T1D |
| TrialNet oral insulin (23) |
Oral insulin prevention trial in first and second degree relatives with insulin antibodies |
No effect in most subjects |
