Figure 5.

Exendin-4 modulates endothelial-cell response after TNF-α stimulation. Iliac Artery Endothelial Cells (IAEC) were stimulated for 24 h with TNF-α (10 ng/mL), Exendin-4 (1 nM and 10 nM) and GLP-1 (10 nM and 100 nM). Protein concentration of VCAM-1 (A), ICAM-1 (B), MMP-1 (C), MMP-9 (D), TIMP1 (E) and TIMP-2 (F). Mean values ± s.e.m. are shown. n = 6 per group. *P < 0.05, **P < 0.01 TNF-α vs different conditions. One-way ANOVA followed with Dunnett’s post hoc.