Figure 1.

Mean serum cortisol (panel A), mean plasma ACTH (panel B), mean plasma total ghrelin (panel C) and mean plasma acyl-ghrelin (panel D) concentration at baseline and after administration of synacthen, metyrapone or hydrocortisone. Hormone concentrations were measured every 30 min for two hours in each phase. Test for difference in means between phases: P = 0.008, P < 0.001, P = 0.031 and P = 0.057 for phase comparisons for mean cortisol, ACTH, total ghrelin and acyl-ghrelin, respectively.