Figure 10.

(a) Chemical structures of conjugated polymer P2, TEM image (Pdots in PBS solution, scale bar = 20 nm), self-assembly, O₂ sensing, and PDT mechanisms of phosphorescent Pdots. Reproduced from Zhou, X.; Liang, H.; Jiang, P.; Zhang, K. Y.; Liu, S.; Yang, T.; Zhao, Q.; Yang, L.; Lv, W.; Yu, Q.; Huang, W., Multifunctional Phosphorescent Conjugated Polymer Dots for Hypoxia Imaging and Photodynamic Therapy of Cancer Cells. Adv. Sci. (Weinheim, Ger.) 2016, 3 (2), 1500155 (ref 86). Copyright 2016 Wiley. In vivo imaging and photodynamic therapy of PFBT-TPP Pdots. (b) Whole-animal imaging of tumor-bearing mice with intratumoral injection of PFBT-TPP Pdots (from top to bottom: bright field, fluorescence, and overlay). (c) Representative photographs of the tumor-bearing mice after various treatments on the first, 14th, and 28th day. The top panel shows control mice with intratumoral Pdot injection only (C1 group), the middle panel shows mice treated with light irradiation only (C2 group), and the bottom panel shows mice treated with intratumoral Pdot injection and light irradiation (PDT group). (d) Representative photographs of the tumors collected from the mice after various treatments. The tumors collected from the C1 group, C2 group, and PDT group were shown in the upper, middle, and lower rows, respectively. (e) Tumor growth curves in the tumor-bearing mice after different treatments. Tumor volumes were normalized to their initial sizes. Error bars represent the standard deviation of 10 mice per group. (f) Time-dependent body weight changes of the mice after various treatments. (g) Histological H&E staining of various organs from the mice of PDT and control groups. Reproduced from Chang, K.; Tang, Y.; Fang, X.; Yin, S.; Xu, H.; Wu, C., Biomacromolecules 2016, 17 (6), 2128–2136 (ref 83). Copyright 2016 American Chemical Society.