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. 2017 Oct 12;8(10):e3096. doi: 10.1038/cddis.2017.477

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The correlation of p53, miR-124 and iASPP expression in CRC tissues. (a) Clinic samples containing diverse p53 levels have been obtained and the pathological states have been assessed. Results showed that the samples possessing higher p53 content had a better pathological condition. (b) miR-124 expression was upregulated in p53wt cells but downregulated in p53mut cells, and the expression levels were altered in a p53 content-dependent manner; iASPP expression was downregulated in p53wt cells but upregulated in p53mut cells, and the expression levels were altered in a p53 content-dependent manner. The data are presented as mean±S.D. of three independent experiments. **P<0.01, ***P<0.005