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Schematic diagram of the role of p53 mutation or knockout in PDT treatment. In the present study, we revealed that p53 promoted miR-124 expression to inhibit iASPP expression, so as to amplify the inhibitory effect of PDT on CRC cell proliferation; after p53 mutation or knockout, miR-124 expression was downregulated while the iASPP expression was upregulated, so that the inhibitory effect of PDT on CRC cell proliferation was reduced
