Table 2. Outcomes of miR-34a modulation in models lacking p53 expression due to genomic deletion.

Cancer type	Target cells	Type of miR-34a modulation	Outcome	Reference
Lung cancer	H1299	Inducible overexpression	Inhibition of migration and invasion	76
	H1299	Transfection of expression plasmid	Inhibition of colony formation, induction of apoptosis	15
	H1299	Introduction of miRNA precursor	Suppressed DNA repair after irradiation, sensitization to radiotherapy in xenograft tumors	115
	H1299	Liposomal in vivo delivery of mature miRNA	Downregulation of immune-suppressive PDL-1, prevention of immune evasion	48
	H358	Introduction of synthetic miRNA oligos	Potentiation of the effect of EGFR inhibition	104
Breast cancer	4T1	Introduction of miRNA precursor	Decreased tumor growth and Treg recruitment	86
Prostate cancer	PC3	Introduction of miRNA precursor	Cell growth inhibition, chemosensitization to camptothecin	116
	PC3	Introduction of synthetic miRNA oligos	Inhibition of cell proliferation, induction of apoptosis	47
	PC3 - taxane resistant	Rubone-induced stabilization combined with paclitaxel	Inhibition of tumor growth, decreased cell viability	113
Gastric cancer	Kato-III	Introduction of miRNA mimics	Growth arrest, chemosensitization and apoptosis	117
Myeloid leukemia	HL-60	Introduction of miRNA precursors/inhibitor	Reduction/restoration of PD-L1 expression and PD-L1 specific T cell apoptosis	31