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The role and molecular mechanism of MBD2 in VAN-induced AKI. After VAN treatment, MBD2 increases its expression by suppression of promoter methylation of miR-301a-5p. Subsequently, upregulation of miR-301a-5p induced cell apoptosis via directly suppressing the expression of HDGF and MITF, and also inhibiting MDM-4 to increase expression of p53
