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. 2017 Oct 12;8(10):e3120. doi: 10.1038/cddis.2017.509

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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VAN-induced apoptosis is attenuated in MBD2-KO mice. Wild-type and MBD2-KO littermate mice were injected with 600 mg/kg VAN (n=8) or saline as control for 7 days. (a) Active caspase 3 and TUNEL assay to reveal apoptosis (original magnification, × 200). Both Active caspase 3 (b) and TUNEL-positive cells (c) were qualified in VAN-treated cortical tissues. Data were expressed as means±S.D.; ^#P<0.05 versus Saline group; *P<0.05 versus VAN group. Data are the representative of at least four separate experiments