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. 2017 Nov 13;3:17070. doi: 10.1038/cddiscovery.2017.70

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Copyright © 2017 The Author(s)

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Cell lysis can be delayed but not prevented following pyroptosis. (a) Overview of sequential stimulation and LDH measurement. (b) LDH release from BMMs treated with RodTox (RTox), RodTox+5 mM glycine (RTox+Gly), or media alone (no stim.) for 90 min. (c) LDH release from BMMs in b following wash and replacement with media±5 mM glycine for 30 min. (d) LDH release from BMMs in c following replacement with a 1% Triton X-100 solution in PBS. Data are depicted as % of LDH release from 1% Triton X-100-treated unstimulated BMMs at each step and are representative of three independent experiments. **P<0.01, ***P<0.001, ****P<0.0001, two-tailed Student’s t-test. RTox, RodTox; Gly, glycine.