Fig. 3.
Cardiac function and T-tubule integrity is normal in MG53-KO mice at 2 and 10 months of age under normal physiological conditions. A, Ejection fraction (EF). B, Ratio of heart weight to body weight (HW/BW). C–E, In vivo hemodynamic measurement of LV development pressure in mice of 10 months old. F–G, Representative confocal T-tubule images in the LV and the RV of hearts from WT and MG53-KO mice at 2 months (F) and 10 months of age (G). H & I, Mean values of TTpower in LV (H) and RV (I) of WT and MG53-KO mice at different ages. N =5 mice in each group. Data shown are mean ±SE.