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. 2017 Sep;187(9):2008–2019. doi: 10.1016/j.ajpath.2017.05.015

Figure 3.

Figure 3

ConA-induced IRF1 expression and JNK activation in HSC-depleted mice. A and B: At 6 hours after ConA administration, HSC-depleted mice show significantly lower hepatic IRF1 mRNA expression (A) and nuclear IRF1 protein levels (B) compared with HSC-sufficient mice. C: JNK activation is reduced in ConA-treated HSC-depleted mice as compared with HSC-sufficient mice. Data are expressed as means ± SD. n = 4 to 6 mice per group (C). ∗P < 0.05, ∗∗P < 0.01 versus control; †P < 0.05 versus HSC-depleted mice. P-JNK, phosphorylated JNK.