Table 1.
Association results for the SNPs investigated.
| Gene | Chr. | SNP Id. | Base Pair Position* | Alleles# | SNP function | MAF (cases) | MAF (controls) | P-value§ |
|---|---|---|---|---|---|---|---|---|
| IL10 | 1 | rs5743626 | 206944285 | C/T | Silent Mutation | 0.27 | 0.29 | 0.87 |
| IL1B | 2 | rs1143643 | 113588302 | C/T | Intron | 0.25 | 0.20 | 0.02 |
| IL1B | 2 | rs1143634 | 113590390 | C/T | Silent Mutation | 0.27 | 0.30 | 0.33 |
| IL1B | 2 | rs16062 | 113591081 | C/T | Silent Mutation | 0.43 | 0.44 | 0.51 |
| TNF | 6 | rs1800629 | 31543031 | A/G | Intron | 0.14 | 0.14 | 0.92 |
| IL6 | 7 | rs2069830 | 22767137 | C/T | Missense Mutation | 0.48 | 0.48 | 0.99 |
| OPG | 8 | rs1131380 | 119938762 | A/C | Missense Mutation | 0.25 | 0.27 | 0.18 |
| RANKL | 13 | rs12721445 | 43180881 | C/T | Missense Mutation | 0.46 | 0.45 | 0.93 |
| RANK | 18 | rs35589394 | 59992591 | C/G | Silent Mutation | 0.49 | 0.50 | 0.76 |
Chr. = Chromosome
*
according to NCBI GRCh37.p10 assembly
#
ancestral allele in bold
MAF = minor allele frequency
§
Chi-square test, significant if P≤0.05