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TLS pathways for replicating through 3-dMeA in human cells. Replication through 3-dMeA occurs via 3 different Polι/Polκ-, Polθ-, and Polζ-dependent pathways and all three pathways mediate error-free TLS through the lesion. The roles of Pols in inserting a nt opposite 3-dMeA and in extension of synthesis from the inserted nt are indicated.
