Fig. 2.
Inhibitory effects of MMPP on accumulation of Aβ1-42 in the brain of LPS-injected mice. (a) Aβ accumulation in the brains of LPS-injected mice was determined by thioflavin S staining. The levels of Aβ1-42 in mice brain (n = 5) were measured by ELISA (b). The activity of β-secretase in mice brain (n = 5) was investigated using assay kit (c). The expression of APP, BACE1 and C99 was detected by Western blotting using specific antibodies in the mouse brain (d). For the cropped images, samples were run in the same gels under same experimental conditions and processed in parallel. Each blot is representative for three experiments