Table 1.
Pharmacokinetic interactions between HC and AEDs
| AED reduced by EE | EE reduced by AED | Progestin reduced by AED | |
|---|---|---|---|
| Old AEDs | |||
| Carbamazepine | NA | Yes | Yes |
| Phenobarbital | NA | Yes | Yes |
| Phenytoin | NA | Yes | Yes |
| Valproate | Yes | No | No |
| New AEDs | |||
| Eslicarbazepine | NA | Yes | Yes |
| Felbamate | NA | Yes | Yes |
| Gabapentin | NA | No | No |
| Lacosamide | No | No | No |
| Lamotrigine | Yes | No | Yes |
| Levetiracetam | No | No | No |
| Oxcarbazepine | NA | Yes | Yes |
| Perampanel | NA | No | Yesa |
| Pregabalin | NA | NA | NA |
| Retigabine/Ezogabine | No | No | No |
| Rufinamide | No | Yes | Yes |
| Stiripentol | NA | NA | NA |
| Topiramate | NA | Yesa | No |
| Zonisamide | No | No | No |
Note:
a
Dose dependent.
Abbreviations: HC, hormonal contraception; AED, antiepileptic drug; EE, ethinyl estradiol; NA, no data available.