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Relationship between Diabetes (hyperglycemia) and Hypertension with Hypoxia. Hypertension mediated increased angiotensin receptor activity and oxidative stress and diabetic mediated mitochondrial dysfunction from excess tubular oxygen consumption lead to a common pathway of tissue hypoxia. The results will include induction of TGF-B among other factors. TGF-B among other factors. TGF-B will be responsible of epithelial to mesenchymal transformation (48).
