Table 4.

Multivariate analysis of the prognostic factors of disease-free survival in colorectal cancer patients

Variable	N	HR	p	95% CI
T stage (TNM)
T1-T2	47	1.0	0.003	2.88–170.7
T3-T4	51	22.1
N stage (TNM)
N0	59	1.0	0.034	1.09–8.41
N+	39	3.03
Primer Pair 2 – ERβ1 and ERβ5 isoforms (loss of relative gene expression (log2)*
≤ −4.5	65	1.0	0.002	1.69–9.84
> −4.5	33	4.08

*The cutoff for relative gene expression (log₂) was determined using the log-rank test (maximally selected rank statistics in R) [24]