Table 3.
GRADE profile evidence of the included studies
| Outcome indicator | No. of studies | Quality assessment | No. of patients | Effect | Quality | Importance | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Risk of bias | Inconsistency | Indirectness | Imprecision | publication bias | LAP | OPEN | Relative (95% CI) | Absolute | ||||
| Operation time | 5 | no serious risk of bias | very seriousa | no serious indirectness | seriousb | None | 90 | 86 | WMD −0.87 (−47.50~47.75) |
⊕⊝⊝⊝ very low |
IMPORTANT | |
| Blood loss | 5 | no serious risk of bias | serious | no serious indirectnessa | seriousb | None | 89 | 108 | WMD −34.38 (−79.60~10.84) |
⊕⊝⊝⊝ very low |
IMPORTANT | |
| Postoperative complications | 6 | no serious risk of bias | no serious inconsistency | no serious indirectness | seriousa | Maybed | 185 | 194 | RR 0.65 (0.38~1.12)c |
⊕ ⊕ ⊝⊝ low |
CRITICAL | |
| Postoperative hospital stay | 6 | no serious risk of bias | very seriousa | no serious indirectness | seriousb | None | 113 | 122 | WMD −2.01 (−3.83~ − 0.18) |
⊕⊝⊝⊝ very low |
IMPORTANT | |
| Overall recurrence rate | 7 | no serious risk of bias | no serious inconsistency | no serious indirectness | seriousa | None | 203 | 214 | RR 0.56 (0.29~1.06)c |
⊕ ⊕ ⊕⊝ moderate |
CRITICAL | |
| Disease-free survival | 5 | no serious risk of bias | no serious inconsistency | no serious indirectness | no serious imprecision | None | 162 | 171 | HR 0.40 (0.17~0.91) |
⊕ ⊕ ⊕⊝ moderate |
CRITICAL | |
| Overall survival | 4 | no serious risk of bias | no serious inconsistency | no serious indirectness | serious | None | 149 | 158 | HR 0.11 (0.03~0.43) |
⊕ ⊕ ⊕⊝ moderate |
CRITICAL | |
LAP laparoscopic resection, OPEN open resection
ahave serious heterogeneity(I 2 > 75%)
bthe sample size of included patients is too small
cthe confidence interval of RR include 1
dexist publication bias