FIGURE 2.

Molecular data in precision oncology. Pediatric cancers may harbor clinically relevant germline and somatic variants, copy number aberrations, gene fusions, and gene expression patterns. Here, the outer circle indicates the type of molecular event. The middle circle indicates the various molecular assays used to profile a given molecular event. The inner circle provides several examples of clinically relevant findings enabled by molecular profiling. WES, whole exome sequencing; WGS, whole genome sequencing; cDNA, complementary DNA; Mut, mutation; Amp, amplification; Del, deletion; Indel, insertion/deletion; SNV, single-nucleotide variant; aCGH, array comparative genome hybridization