Figure 2.
Smoking-Related miRNAs Alter Cytokine Expression in Vitro. Multiplex cytokine bead array analysis of A549 cell culture supernatants after transfection with non-targeting (NT), miR-1180, or miR-1285-3p mimetics. Cells were stimulated 24 hours post-transfection with vehicle or 10 ng/mL rhTNF-α for 6 hours. Squares, triangles, and circles represent data collected from three independent experiments, normalized to the cytokine concentrations in the negative control group (NT vehicle). The * indicates p<0.01 (significant p-values shown) when compared to NT control within a given stimulation group as determined by a two-way ANOVA followed by Dunnett’s test, using raw rather than normalized values.