Table 3.

Trends in the prescription of antibacterial compounds and for the main resistance phenotypes

	Gradient per quarter	Gradient (95% CI)	R 2	p value	Trend
Penicilins*	14.61	(0.85; 28.26)	0.529	0.041	↑
Piperacillin + tazobactam*	10.91	(3.74; 18.08)	0.698	0.010	↑
Ampicillin + enzyme inhibitor	3.27	(− 11.14; 17.67)	0.049	0.599	↔
Amoxicillin + enzyme inhibitor	0.34	(− 1.72; 2.39)	0.026	0.702	↔
Cephalosporins	− 15.95	(− 34.73; 2.82)	0.419	0.083	↔
Ceftriaxone*	− 28.23	(− 47.55; − 8.91)	0.681	0.012	↓
Cefuroxime	3.48	(− 5.60; 12.56)	0.128	0.385	↔
Carbapenems*	13.12	(0.48; 25.75)	0.518	0.044	↑
Imipenem + enzyme inhibitor	1.55	(− 4.57; 7.68)	0.060	0.558	↔
Meropenem*	14.63	(6.25; 23.00)	0.753	0.005	↑
Ertapenem	− 3.06	(− 8.76; 2.63)	0.224	0.237	↔
Fluoroquinolones	− 0.60	(− 7.81; 6.60)	0.007	0.844	↔
Aminoglycosides	1.74	(− 1.96; 5.44)	0.180	0.294	↔
Other*	27.90	(10.37; 45.44)	0.717	0.008	↑
MRSA	0.10	(− 0.96; 1.16)	0.009	0.824	↔
ESBL E. coli	0.12	(− 0.08; 0.33)	0.261	0.196	↔
ESBL K. pneumoniae	− 0.08	(− 1.05; 0.90)	0.006	0.850	↔
ESBL P. mirabilis	− 0.15	(− 0.66; 0.37)	0.074	0.515	↔
Combined-resistant P. aeruginosa*	0.78	(0.27; 1.28)	0.707	0.009	↑
Carbapenem-resistant Ps. aeruginosa*	0.74	(0.21; 1.27)	0.666	0.013	↑
Carbapenem-resistant A. baumannii	− 0.10	(− 0.59; 3.99)	0.039	0.641	↔

* Results where R² > 0.3 and p ≤ 0.05