Table 4.
Genotype distribution under dominant and recessive models and allele frequencies of the rs1799983, Intron 4 VNTR and rs2070744 in patients and control groups
| Patients n(%) | Controls n(%) | ||||
|---|---|---|---|---|---|
| rs1799983 | Dominant model | GG | 99 (67.3%) | 60 (73.2%) | χ2 = 0.84 P = 0.36 OR (95% CI) = 0.76 (0.42–1.4) |
| GT + TT | 48 (32.7%) | 22 (26.8%) | |||
| Recessive model | GG + GT | 142 (96.6%) | 80 (97.6%) | χ2 = 0.17 P = 0.69 OR (95% CI) = 0.71 (0.14–3.74) |
|
| TT | 5 (3.4%) | 2 (2.4%) | |||
| Allele frequency | G | 242 (82.3%) | 140 (85.4%) | χ2 = 0.71 P = 0.40 OR (95% CI) = 0.80 (0.47–1.35) |
|
| T | 52 (17.7%) | 24 (14.6%) | |||
| Intron 4 VNTR | Dominant model | bb | 144 (95.4%) | 75 (96.2%) | χ2 = 0.08 P = 0.78 OR (95% CI) = 0.82(0.21–3.3) |
| ab + aa | 7 (4.6%) | 3 (3.8%) | |||
| Recessive model | bb + ab | 83 (55%) | 50 (64.1%) | χ2 = 1.76 P = 0.18 OR (95% CI) = 0.68 (0.39–1.2) |
|
| aa | 68 (45%) | 28 (35.9%) | |||
| Allele frequency | b | 227 (75.2%) | 125 (80.1%) | χ2 = 1.42 P = 0.23 OR (95% CI) = 1.33 (0.83–2.14) |
|
| a | 75 (24.8%) | 31 (19.9%) | |||
| rs2070744 | Dominant model | TT | 72 (47.4%) | 54 (65.9%) | χ2 = 7.32 P = 0.007 OR (95% CI) = 2.14 (1.23–3.74) |
| TC + CC | 80 (52.6%) | 28 (34.1%) | |||
| Recessive model | TT + TC | 142 (93.4%) | 78 (95.1%) | χ2 = 0.27 P = 0.60 OR (95% CI) = 0.73 (0.22–2.4) |
|
| CC | 10 (6.6%) | 4 (4.9%) | |||
| Allele frequency | T | 214 (70.4%) | 131 (79.9%) | χ2 = 4.95 P = 0.03 OR (95% CI) = 1.84 (1.15–2.93) |
|
| C | 90 (29.6%) | 33 (20.1%) | |||
Binary logistic regressions were tested for all the three polymorphisms with age, gender and smoking as covariates and none had an effect on the genotype distribution under dominant and recessive models