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. 2017 Nov 13;17:761. doi: 10.1186/s12885-017-3711-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Differentially expressed miRNAs in eBL compared to GC B cells. a. Heatmap of differentially expressed (DE) miRNAs between eBL tumor cells and GC (Germinal center) B cells. The heatmap shows the hierarchical clustering based on the expression profiles of the 49 DE miRNAs with at least 2-fold difference in expression compared to their normal counterpart. b. Volcano plot representing the significance miRNAs (−log of the adjusted p-value) vs the fold change difference in eBL compared to GC B-cells. The red and blue colored circles represent miRNAs which are DE with p < 0.01 and FDR < 0.01. The 27 down-regulated miRNAs in eBL are colored blue (have a negative fold-change value) while the 22 up-regulated miRNAs in eBL are colored red (positive fold-change value)