Table 1.
Differentially expressed miRNAs between eBL tumor cells and GC B cells (logFC > 2, p-value < 0.01 and FDR < 0.01)
| miRNA name | Log FC eBL versus GC B cells | BH adjusted p-value | FDR | Regulation eBL versus GC B cells |
|---|---|---|---|---|
| Upregulated miRs | ||||
| hsa-miR-486-5p | 10.6609 | 1.38E-20 | 1.19E-19 | Up |
| hsa-miR-182-5p | 8.9478 | 4.55E-26 | 4.63E-25 | Up |
| hsa-miR-10a-5p | 6.1349 | 3.60E-09 | 1.19E-08 | Up |
| hsa-miR-183-5p | 5.7463 | 2.02E-15 | 1.19E-14 | Up |
| hsa-miR-22-3p | 5.5587 | 7.96E-17 | 4.95E-16 | Up |
| hsa-miR-19b-3p | 4.7807 | 3.32E-13 | 1.43E-12 | Up |
| hsa-miR-186-5p | 4.3815 | 3.43E-19 | 2.56E-18 | Up |
| hsa-miR-92b-3p | 4.0673 | 3.01E-12 | 1.16E-11 | Up |
| hsa-miR-769-5p | 3.9268 | 7.24E-12 | 2.70E-11 | Up |
| hsa-miR-27b-3p | 3.8964 | 4.25E-14 | 2.07E-13 | Up |
| hsa-miR-30b-5p | 3.5192 | 9.55E-11 | 3.45E-10 | Up |
| hsa-miR-146b-5p | 3.4102 | 8.07E-10 | 2.74E-09 | Up |
| hsa-miR-532-5p | 3.1493 | 2.26E-10 | 7.93E-10 | Up |
| hsa-miR-660-5p | 3.1183 | 6.35E-09 | 2.03E-08 | Up |
| hsa-miR-26a-5p | 3.0639 | 2.38E-07 | 6.65E-07 | Up |
| hsa-miR-130a-3p | 3.0018 | 3.50E-05 | 7.13E-05 | Up |
| hsa-miR-21-3p | 2.7137 | 2.29E-06 | 5.58E-06 | Up |
| hsa-miR-92a-3p | 2.6837 | 2.11E-08 | 6.58E-08 | Up |
| hsa-miR-148a-3p | 2.6221 | 2.61E-07 | 7.14E-07 | Up |
| hsa-miR-99b-5p | 2.4566 | 1.97E-04 | 3.74E-04 | Up |
| hsa-miR-3615 | 2.2328 | 1.23E-05 | 2.65E-05 | Up |
| hsa-miR-340-5p | 2.1321 | 2.30E-04 | 4.30E-04 | Up |
| Downregulated miRs | ||||
| hsa-miR-423-5p | −6.82082 | 6.92E-38 | 2.59E-36 | Down |
| hsa-miR-331-3p | −6.22424 | 4.78E-28 | 6.70E-27 | Down |
| hsa-miR-222-3p | −5.76142 | 3.31E-29 | 6.18E-28 | Down |
| hsa-miR-140-3p | −5.67778 | 1.03E-52 | 1.16E-50 | Down |
| hsa-let-7d-5p | −5.54828 | 1.29E-27 | 1.61E-26 | Down |
| hsa-miR-320a | −5.12011 | 3.82E-38 | 2.14E-36 | Down |
| hsa-miR-29a-3p | −4.80203 | 4.01E-36 | 1.12E-34 | Down |
| hsa-let-7 g-5p | −4.78494 | 3.71E-18 | 2.46E-17 | Down |
| hsa-let-7f-5p | −4.52246 | 4.60E-23 | 4.29E-22 | Down |
| hsa-miR-221-3p | −4.50804 | 1.18E-33 | 2.64E-32 | Down |
| hsa-let-7e-5p | −4.44258 | 6.34E-27 | 7.10E-26 | Down |
| hsa-let-7b-5p | −3.90908 | 2.16E-15 | 1.21E-14 | Down |
| hsa-miR-28-5p | −3.85689 | 6.16E-29 | 9.86E-28 | Down |
| hsa-let-7a-5p | −3.79827 | 1.52E-20 | 1.22E-19 | Down |
| hsa-miR-1260a | −3.32632 | 7.61E-14 | 3.55E-13 | Down |
| hsa-miR-103a-3p | −3.23483 | 3.74E-18 | 2.46E-17 | Down |
| hsa-miR-1260b | −3.16842 | 1.42E-12 | 5.91E-12 | Down |
| hsa-miR-30e-3p | −3.00521 | 8.00E-15 | 4.27E-14 | Down |
| hsa-let-7c | −2.98489 | 3.79E-14 | 1.93E-13 | Down |
| hsa-miR-29c-3p | −2.90631 | 2.48E-13 | 1.11E-12 | Down |
| hsa-miR-107 | −2.89683 | 2.00E-12 | 8.00E-12 | Down |
| hsa-miR-1275 | −2.52971 | 1.30E-05 | 2.74E-05 | Down |
| hsa-miR-15b-5p | −2.17524 | 4.93E-08 | 1.45E-07 | Down |
| hsa-miR-423-3p | −2.15549 | 7.20E-07 | 1.92E-06 | Down |
| hsa-miR-378i | −2.13256 | 1.86E-06 | 4.64E-06 | Down |
| hsa-miR-155-5p | −2.07727 | 8.29E-06 | 1.82E-05 | Down |
| hsa-miR-21-5p | −2.02446 | 4.01E-08 | 1.22E-07 | Down |
Abbreviations: eBL endemic Burkitt lymphoma, GC germinal center, BH Benjamini & Hochberg, FC Fold Change, FDR False discovery rate