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The effect of TERT promoter mutations on reporter gene activity. SW1736 cells were transfected (in triplicate) with TERT‐LUC, TERTC228T‐LUC or TERTC250T‐LUC as shown and treated with vehicle or the MEK inhibitor U0126. Luciferase activity was measured in cell lysates 48 h after transfection and normalised for Renilla luciferase as a transfection control. Data shown are mean ± SD from three experiments. *P < 0·01.
