Table 2.
The distribution of genotypes and alleles of Arg399Gln of gene XRCC1, Arg72Pro of gene TP53 and T309G of gene MDM2 in BC patients of Kyrgyz ethnicity compared to healthy controls
| Markers | Alleles and genotypes | Cases, n (%) | Controls, n (%) | χ2 | р | OR | CI 95% |
|---|---|---|---|---|---|---|---|
|
Arg399Gln
gene XRCC1 rs25487 |
Allele Arg399 | 144 (62) | 146 (72) | 4.46 | 0.034 | 0.64 | 0.42–0.95 |
| Allele 399Gln | 90 (38) | 58 (28) | 1.57 | 1.05–2.35 | |||
| Arg399Arg | 38 (32) | 56 (55) | 13.86 | 0.0010 | 0.39 | 0.22–0.68 | |
| Arg399Gln | 68 (58) | 34 (33) | 2.77 | 1.60–4.80 | |||
| Gln399Gln | 11 (10) | 12 (12) | 0.77 | 0.32–1.84 | |||
| HWE χ2 /р | 6.07/0.01 | 3.33/0.06 | |||||
|
Arg72Pro
gene TP53 rs1042522 |
Allele Arg72 | 164 (70) | 142 (70) | 0.011 | 0.913 | 1.02 | 0.68–1.54 |
| Allele 72Pro | 70 (30) | 62 (30) | 0.98 | 0.65–1.47 | |||
| Arg72Arg | 57(49) | 53 (52) | 1.80 | 0.41 | 0.88 | 0.52–1.49 | |
| Arg72Pro | 50 (43) | 36 (35) | 1.37 | 0.79–2.36 | |||
| Pro 72Pro | 10 (8) | 13 (13) | 0.64 | 0.27–1.53 | |||
| HWE χ2 /р | 0.04/0.83 | 2.80/0.09 | |||||
|
T309G
gene MDM2 rs2279744 |
Allele T309 | 120 (49) | 111(46) | 0.31 | 0.58 | 0.88 | 0.60–1.28 |
| Allele 309G | 114 (51) | 93 (54) | 1.13 | 0.77–1.65 | |||
| G309G | 29 (24) | 28 (27) | 0.500 | 0.77 | 0.87 | 0.47–1.59 | |
| T309G | 62 (53) | 55 (54) | 0.96 | 0.56–1.64 | |||
| T309 T | 26 (22) | 19 (18) | 1.24 | 0.64–2.42 | |||
| HWE χ2 /р | 0.42/0.51 | 0.77/0.38 | |||||
OR odds ratio, CI confidence interval, HWE Hardy-Weinberg equilibrium