Fig. 3.

Hub genes detection and protein-protein network (PPI). (A) Scatter plot of module eigengenes in green module. (B) The Venn diagram of co-expression hub genes and PPI network hub genes. (C) Protein–protein interaction network of genes in the green module. The color intensity in each node was proportional to fold change of expression in comparison to normal kidney samples (up-regulation in red and down-regulation in green). The nodes with bold circle represented network hub genes identified by WGCNA. The edge width was proportional to the score of protein-protein interaction based on the STRING database. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)