Figure 2.

iECV as a Marker of Extracellular Expansion in the Myocardium

(A) Regions of interest manually drawn onto native and post-contrast T1 maps are used to calculate indexed extracellular volume (iECV). (B) Histology from a patient with aortic stenosis (AS) with areas of diffuse fibrosis stained with picrosirus red. (C) Excellent correlation between iECV and diffuse myocardial fibrosis on histology. (D) iECV provided good discrimination between disease states. (E) iECV values were higher in patients with replacement fibrosis than patients with normal myocardium or extracellular expansion.