Table 1.

Overview of the study design

	Single ascending dose	Multiple ascending dose
Study 001 (Single ascending-dose study, ClinicalTrials.gov identifier: NCT01285388)	10, 30, 100, 150 and 200 mg
Study 002 (Single and multiple ascending-dose study, ClinicalTrials.gov identifier: NCT01444677)	300 and 400 mg	100 and 200 mg