Figure 3.
ATGL-Mediated Lipolysis in WAT Is Essential to Fuel Thermogenesis during Fasting
(A and C) Body temperature in iBAKO (A) and AAKO (C) mice during fasting at 5°C at indicated time points.
(B and D) Blood glucose, plasma FA, glycerol, and TG levels upon fasting at 5°C for 6 hr in iBAKO mice (B) (n = 5–8) and for 2 hr in AAKO mice (D) (n = 7).
Analyses were performed in female iBAKO and ATGLflox/flox mice aged 40 weeks and 8 weeks upon tamoxifen administration and AAKO mice of mixed sex aged 10–16 weeks. Data are presented as means ± SD. Statistical significance was evaluated by unpaired two-tailed Student’s t test. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001. See also Figure S3.