Table 3.
Diagnostic Performance of Clinical Characteristics for Excluding a Pathologic Murmur
| Characteristic | PPV, % (95% CI) | Specificity, % (95% CI) | Sensitivity, % (95% CI) |
|---|---|---|---|
| Disappearance on standing | 98 (93–100) | 93 (78–99) | 60 (52–67) |
| Conventionally used characteristics | |||
| Low to middle left sternal border location | 93 (87–96) | 67 (47–83) | 82 (75–88) |
| Diminution or disappearance on standing | 91 (86–95) | 53 (34–72) | 90 (85–94) |
| No radiation | 87 (81–92) | 33 (17–53) | 85 (78–90) |
| No symptoms | 86 (80–91) | 20 (7–39) | 91 (86–95) |
| Systolic timing | 85 (79–90) | 3 (0–17) | 100 (98–100) |
PPV=positive predictive value.