Table 2.
Linear mixed model estimates and 95% confidence intervals for weight gain and nutrition parameters for preterm lambs managed by non-invasive support (NIS) for 21 days.
| NIS (n=5) | Difference from NIS | |||
|---|---|---|---|---|
| NIS+RN (n=4) | NIS+ES (n=4) | |||
| Weight Gain at DOL20 (Kg) | 1.46 (0.97~1.94) | −1.24 (−1.97~−0.51)* | 0.37 (−0.36~1.10) | |
| Daily Weight Gain (Kg) | Phase 11 | 0.05 (0.01~0.08) | ≤0.00 (−0.06~0.06) | 0.03 (−0.03~0.09) |
| Phase 22 | 0.19 (0.15~0.23) | −0.19 (−0.25~−0.13)* | ≤0.00 (−0.06~0.06) | |
| Total Calories on DOL20 (kcal/Kg) | 283 (249~318) | −211 (−262~−159)* | −41 (−93~10) | |
| Daily Change in Calories (kcal/Kg) | Phase 1 | 8 (6~11) | 1 (−3~5) | 7 (3~11)* |
| Phase 2 | 15 (11~ 20) | −29 (−36~−23)* | −15 (−21~−8)* | |
| Total Fluid on DOL20 (mL/Kg) | 283 (245~320) | −136 (−193~−79)* | −31 (−88 ~26) | |
| Daily Change in Fluid Intake (mL/Kg) | Phase 1 | 4 (1~7) | 1 (−4~5) | 6 (1~10)* |
| Phase 2 | 6 (1~10) | −18 (−25 ~−12)* | −8 (−14~−1)* | |
| Protein on DOL20 (g/Kg) | 15.6 (13.7~17.6) | −12.2 (−15.2~−9.3)* | −2.1 (−5.1~0.8) | |
| Daily Change in Protein Intake (g/Kg) | Phase 1 | 0.6 (0.5~0.8) | 0.1 (−0.2~0.3) | 0.4 (0.2~0.6)* |
| Phase 2 | 0.8 (0.6~1.1) | −1.7 (−2.1~−1.3)* | −0.8 (−1.2~−0.4)* | |
| Fat on DOL20 (g/Kg) | 18.3 (16.0~20.5) | −14.0 (−17.5~−10.8)* | −2.6 (−5.9~0.8) | |
| Daily Change in Fat Intake (g/Kg) | Phase 1 | 0.7 (0.6~0.9) | 0.1 (−0.2~0.4) | 0.5 (0.2~0.7)* |
| Phase 2 | 1.0 (0.7~1.3) | −2.0 (−2.4~−1.5)* | −0.9 (−1.4~−0.5)* | |
1
Phase 1 is postnatal DOL 5–12 for weight gain, and DOL 1–12 for all other parameters
2
Phase 2 is postnatal DOL 13–20
*
Significantly different from NIS
DOL, day of life; NIS, non-invasive support; RN, restricted nutrition; ES, excess sedation